[PDF] Refractory Pseudomonas Osteomyelitis of the Skull Base With Gradenigo’s Syndrome: Early Dysphagia and Late Abducens Nerve Palsy | Semantic Scholar (2024)

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@article{Mammarella2024RefractoryPO, title={Refractory Pseudomonas Osteomyelitis of the Skull Base With Gradenigo’s Syndrome: Early Dysphagia and Late Abducens Nerve Palsy}, author={Fulvio Mammarella and Antonella Loperfido and Gianluca Velletrani and Francesco Casorati and Alessandro Stasolla and Stefano Di Girolamo and Gianluca Bellocchi}, journal={Journal of Medical Cases}, year={2024}, volume={15}, pages={43 - 48}, url={https://api.semanticscholar.org/CorpusID:269245795}}
  • F. Mammarella, A. Loperfido, G. Bellocchi
  • Published in Journal of Medical Cases 1 April 2024
  • Medicine

A 71-year-old man with a previous history of otitis media and poorly controlled type 2 diabetes mellitus with facial pain, left hemilarynx paralysis, dysphagia and otorrhea is presented, the only case with a delayed onset of abducens nerve palsy.

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38 References

Steroid-Responsive Gradenigo’s Syndrome Mimicking Subdural Hematoma
    Yi LiuPo-Kuan YehYu-Pang LinY. Sung

    Medicine

    Cureus

  • 2021

A Gradenigo's syndrome caused by chronic inflammation with good response to steroids is reported, a 35-year-old female who presented with right temporal headache and right retro-orbital pain and the MRI performed after three months recorded no brain inflammation.

  • 5
  • Highly Influential
  • PDF
Transmastoid and Transtemporal Drainage of Petrous Apicitis with Otitis Media
    Heba IsaacAndrew LiuS. B. ShibataM. Hansen

    Medicine

    The Annals of otology, rhinology, and laryngology

  • 2020

While a variety of different surgical approaches can be used in treatment of PA, the MCF approach is recommended in cases where access to the anterior petrous apex may be challenging via transcanal or transmastoid approach.

  • 6
  • Highly Influential
Gradenigo’s Syndrome and Vernet Syndrome as Presenting Signs of Nasopharyngeal Carcinoma
    Ciji RobinsonDiva C MarajJasdeep S MinhasMehakmeet BhatiaV. Kak

    Medicine

    Cureus

  • 2023

A patient presenting with symptoms reflective of a sinus infection unrelieved by antibiotics with concomitant cranial nerve deficits should raise clinical concern for an intracranial pathology rather than a simple case of sinusitis.

Gradenigo’s Syndrome With Septic Lateral Sinus Thrombosis
    Tiago BrancoCatarina MarquesV. SantosJ. M. Lopes

    Medicine

    Cureus

  • 2023

The case of an 81-year-old man with a previous history of recurrent otitis media, who presented withGradenigo’s syndrome and septic lateral sinus thrombosis is presented.

Petrositis caused by fluconazole-resistant candida: case report and literature review
    Ling JinShuangxi LiuShiwang TanYang WangYumin ZhaoShao-qing Yu

    Medicine

    BMC Infectious Diseases

  • 2022

Drug treatment is conservative but efficient method in this case of fungal petrositis, and mNGS can provide pathogenic reference, when antibiotic is not efficient enough for fungal infections or drug-resistantfungal infections cases.

  • 3
  • PDF
Atypical Gradenigo Syndrome in an Elderly Man Resolved with Mastoidectomy and Petrous Apicectomy
    Azizullah BeranNameer Aladamat Ammar Kayyali

    Medicine

    European journal of case reports in internal…

  • 2022

A 67-year-old man who presented with an incomplete triad of symptoms of GS that failed medical therapy and was successfully treated with surgical intervention (mastoidectomy and petrous apicectomy) is presented.

  • 3
  • PDF
Case Report: Diagnosis of Petrous Apex IgG4-Related Disease by Middle Cranial Fossa Craniotomy and Temporal Bone Biopsy
    L. HofmeyrGerrida HerbstE. PretoriusB. SarembockKathryn R. TaylorD. Roytowski

    Medicine

    Frontiers in Neurology

  • 2022

This study describes a case of primary IgG4-RD of the petrous apex of the temporal bone that presented with diplopia and was diagnosed by middle fossa craniotomy and temporal bone biopsy, thought to be the first case description where primary diagnosis was made based on middle cranial fosso craniotom and temporalBone biopsy.

  • 2
  • PDF
Gradenigo's syndrome presenting as IX and X cranial nerve palsy without clinically apparent ear infection: A case report and review of literature
    Safia BanoA. NawazAbyaz AsmarM. A. U. RehmanHareem FarooqH. Ali

    Medicine

    eNeurologicalSci

  • 2022
  • 8
  • PDF
An unusual case of acute otitis media resulting in Gradenigo syndrome: CT and MRI findings
    J. QuesadaA. KongE. Tweddle

    Medicine

    Radiology case reports

  • 2021
  • 5
  • PDF
Petrous apicitis presenting with Horner’s syndrome
    Sidonie E. IbrikjiNesreen RizkR. Sawaya

    Medicine

    Acta Neurologica Belgica

  • 2021

The classic clinical constellation of this entity, referred to as Gradenigo’s triad, consists of an ipsilateral abducens nerve palsy, severe pain in the trigeminal nerve distribution, and bacterial otitis media.

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    [PDF] Refractory Pseudomonas Osteomyelitis of the Skull Base With Gradenigo’s Syndrome: Early Dysphagia and Late Abducens Nerve Palsy | Semantic Scholar (2024)

    FAQs

    What is Gradenigo syndrome nerve palsy? ›

    Gradenigo's syndrome (GS) is a triad (otorrhea, abducens nerve palsy, and pain in the trigeminal nerve distribution) of clinical findings that are caused by contiguous spread of petrous apicitis to the nearby neurovascular structures.

    Does sixth nerve palsy go away? ›

    Often, symptoms from sixth nerve palsy improve on their own. Sixth nerve palsy following a viral illness often completely goes away within a few months. Symptoms following trauma may also improve over several months. But in cases of trauma, symptoms are less likely to go away completely.

    What are the symptoms of cn6 palsy? ›

    The main symptoms of sixth nerve palsy include:
    • Eye misalignment (strabismus). If an affected eye can't turn outward properly, it may cause a misalignment that's visible to others. ...
    • Double vision (diplopia). ...
    • Changing position to see better. ...
    • Nausea and vomiting. ...
    • Pain.
    Dec 19, 2023

    What is 6th and 7th nerve palsy syndrome? ›

    Moebius syndrome is a rare neurological disorder characterized by weakness or paralysis (palsy) of multiple cranial nerves, most often the 6th (abducens) and 7th (facial) nerves. Other cranial nerves are sometimes affected. The disorder is present at birth (congenital).

    How do you treat Gradenigo's syndrome? ›

    High-dose antibiotic treatment is the most common form of medical therapy. Multiple reported cases of GS involved infection by Staphylococcus or Streptococcus bacteria. Cephalosporins were the most common antibiotics prescribed, in addition to penicillin, ampicillin, and vancomycin.

    How do you fix cranial nerve palsy? ›

    The types of treatment options for cranial nerve disorders include:
    1. Medication. ...
    2. Microvascular Decompression (MVD) ...
    3. Gamma Knife® Perfexion™ Radiosurgery. ...
    4. Supra Orbital and Infra Orbital Peripheral Nerve Stimulation. ...
    5. Percutaneous Glycerol Rhizotomy. ...
    6. Research and Clinical Trials.

    Can you drive with 6th nerve palsy? ›

    Advice on paralysis of the III cranial pair, paralysis of cranial pairs IV and VI and disorders of conjugated eye movements. Pupillary areflexia that hinder the visual capacity established by the law leads not to driving. The patient with diplopia must not drive.

    Can anxiety cause 6th nerve palsy? ›

    Certainly emotional stress is an uncommon cause for vasculopathic cranial nerve palsy. For example, during the time period in which these three patients were seen, we examined 112 and 91 cases of vasculopathic 6th and 3rd nerve palsy, respectively in which stress was not an apparent factor.

    What kind of trauma causes 6th nerve palsy? ›

    Post-traumatic sixth nerve palsy is usually a result of severe head or facial trauma and is associated with loss of consciousness. This may occur in the presence or absence of a skull base or cervical fracture. Unilateral abducens nerve palsy occurs in 1%-2.7% of all head traumas.

    Are there warning signs before Bell's palsy? ›

    Many people feel discomfort behind the ear before weakness is noticed. The face feels stiff or pulled to one side and may look different. Other signs can include: Difficulty closing one eye.

    What does cranial nerve palsy look like? ›

    Third cranial nerve palsies can result in drooping of the eyelid (ptosis) and an outward drifting of the eye (exotropia). ). The affected eye is unable to look in towards the nose, up, or down. Sometimes the pupil is also abnormally enlarged on that side.

    What can be mistaken for Bell's palsy? ›

    Two different conditions can cause the same problem of single-sided facial paralysis: stroke or Bell's Palsy. In both of these conditions, symptoms can occur, like the inability to close the eye and facial drooping on the affected side.

    Is 6th nerve palsy permanent? ›

    This may temporarily weaken the movement of your eye muscle. If your condition is caused by viral illness or an unknown cause, it's likely to completely disappear. You may never fully recover, though, if your sixth nerve palsy is due to trauma. Some people may have permanent vision changes.

    Can you recover from 6th nerve palsy? ›

    In all, 78.4% of patients experienced spontaneous recovery of their palsy, 36.6% recovering by 8 weeks and 73.7% by 24 weeks.

    What is another name for 6th nerve palsy? ›

    Abducens (sixth cranial) nerve palsy is the most common ocular motor paralysis in adults and the second-most common in children. The abducens nerve controls the lateral rectus muscle, which abducts the eye. Abducens nerve palsy causes an esotropia due to the unopposed action of the antagonistic medial rectus muscle.

    What is the most common cause of cranial nerve palsy? ›

    Microvascular cranial nerve palsy can develop in people who have high blood pressure. Children are sometimes born with third nerve palsy. But it may also be caused by a head injury or an infection. A disorder affecting the brain, such as an aneurysm or brain tumor, may also cause third nerve palsy.

    What is CN 3 palsy called? ›

    An acquired oculomotor nerve palsy (OMP) results from damage to the third cranial nerve. It can present in different ways causing somatic extraocular muscle dysfunction (superior, inferior, and medial recti; inferior oblique; and levator palpebrae superioris) and autonomic (pupillary sphincter and ciliary) muscles.

    What happens if the cranial nerve 11 is damaged? ›

    Trapezius muscle paralysis secondary to SAN injury causes the affected shoulder to droop and the scapular appearance is consistent with lateral winging. Compared to the normal side, the clinician should appreciate inferior translation of the scapula, and the inferior angle is rotated laterally.

    What are the symptoms of microvascular cranial nerve palsy? ›

    The most common microvascular cranial nerve palsy (MCNP) symptoms are problems moving your eyes, blurry vision and double vision. You may find that it takes longer than usual to move your eyes. Or you may not be able to move your eyes at all in one or more directions. In some cases, you may have vertical double vision.

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